The third rate-limiting step in metastasis involves a forking point where tumor cells can either proliferate inside organ microvessels until the metastatic tumor outgrows the blood vessel and invades distant organ parenchyma [ 69], or extravasate before starting secondary tumor growth. Invasive propensity involves a series of tumor cell interactions with ECM proteins associated with the basement membrane and target organ stroma. MCP has been shown to reduce Gal-3-mediated tumor cell interactions with ECM proteins such as laminin [ 66]. Also, citrus pectin polysaccharides dose-dependently decreased the invasion through matrigel of human endothelial cells [ 67], of MDA-MB-231 human metastatic breast carcinoma cells [ 70], and human buccal metastatic cells [ 70]. Olano-Martin, E., Rimbach, G. H., Gibson, G. R., and Rastall, R. A. (2003). Pectin and pectic-oligosaccharides induce apoptosis in in vitro human colonic adenocarcinoma cells. Anticancer Res. 23, 341–346. CP and mainly MCP have an immunomodulatory effect on the levels of cytokine secretion in the spleen of mice with a pro-inflammatory potential Kolar, S. S., Barhoumi, R., Callaway, E. S., Fan, Y. Y., Wang, N., Lupton, J. R., et al. (2007). Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G935–G943. doi: 10.1152/ajpgi.00312.2007

PectaSol Capsules | Clinically-Proven Modified Citrus Pectin PectaSol Capsules | Clinically-Proven Modified Citrus Pectin

Avivi-Green, C., Polak-Charcon, S., Madar, Z., and Schwartz, B. (2000c). Dietary regulation and localization of apoptosis cascade proteins in the colonic crypt. J. Cell. Biochem. 77, 18–29. doi: 10.1002/(SICI)1097-4644(20000401)77:1<18::AID-JCB3>3.0.CO;2-1 Wong, T. W., Colombo, G., and Sonvico, F. (2011). Pectin matrix as oral drug delivery vehicle for colon cancer treatment. AAPS PharmSciTech 12, 201–214. doi: 10.1208/s12249-010-9564-z Mantovani A, Marchesi F, Malesci A, Laghi L, Allavena P. Tumour-associated macrophages as treatment targets in oncology. Nat Rev Clin Oncol. 2017;14:399–416. Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironmentMatarrese P, Tinari N, Semeraro ML, Natoli C, Iacobelli S, Malorni W. Galectin-3 overexpression protects from cell damage and death by influencing mitochondrial homeostasis. FEBS Lett. 2000;473:311–5. Food supplements should not be used as a substitute for a varied diet. If you are taking prescribed medication, have any medical condition or are pregnant or breast-feeding please consult your healthcare practitioner before taking food supplements. Take 6 capsules daily, (3 capsules, twice daily) with liquid on any empty stomach or as recommended by your healthcare practitioner. This product is designed to be taken on an empty stomach, at least 30 minutes before or 2 hours after food, or 2 hours either before or after other supplements or medications.

PectaSol-C modified citrus pectin induces apoptosis and PectaSol-C modified citrus pectin induces apoptosis and

After the initial parking in distant organs and extravasation, the overwhelming majority of cancer cells undergo apoptosis caused by various factors, and only ~2% survive and lead to micrometastasis [ 71]. Clonogenicity survival of early metastatic colonies is, therefore, the fourth rate-limiting step in metastasis. Galectin-3 protects cancer cells from different types of apoptosis by acting on mitochondrial pathways [ 72, 73, 74]. Some have suggested that MCP could undo Gal-3 anti-apoptotic function, thereby reducing the clonogenicity survival of cancer cells [ 74]. MCP dose-dependently inhibited the clonogenicity survival of hemangiosarcoma cells, and this was associated with increased tumor cell apoptosis [ 75]. Cho, Y., Turner, N. D., Davidson, L. A., Chapkin, R. S., Carroll, R. J., and Lupton, J. R. (2012). A chemoprotective fish oil/pectin diet enhances apoptosis via Bcl-2 promoter methylation in rat azoxymethane-induced carcinomas. Exp. Biol. Med. (Maywood) 237, 1387–1393. doi: 10.1258/ebm.2012.012244 Yan J, Katz A. PectaSol-C modified citrus pectin induces apoptosis and inhibition of proliferation in human and mouse androgen-dependent and -independent prostate cancer cells. Integr Cancer Ther. 2010;9:197–203. As a dietary supplement, take 1 scoop per day on an empty stomach, or as recommended by your healthcare practitioner. For maximum support, take 3 scoops per day on an empty stomach. Can be mixed with water, juice, or hot beverages. For best mixing results, add to warm or room temperature liquid and wait 5 minutes before stirring thoroughly. MCP: Honokiol (9:1) combination induced a synergistic effect on antioxidant activity suggesting that the mixture is significantly more efficient than individual compoundsIn experimental models of mild kidney damage, the increase in renal Gal-3 expression paralleled with renal fibrosis and inflammation, while these alterations prevented with MCP Harrison SA, Marri SR, Chalasani N, Kohli R, Aronstein W, Thompson GA, et al. Randomised clinical study: GR-MD-02, a galectin-3 inhibitor, vs. placebo in patients having non-alcoholic steatohepatitis with advanced fibrosis. Aliment Pharmacol Ther. 2016;44:1183–98. Iwasaki K, Yabushita H, Ueno T, Wakatsuki A. Role of hypoxia-inducible factor-1alpha, carbonic anhydrase-IX, glucose transporter-1 and vascular endothelial growth factor associated with lymph node metastasis and recurrence in patients with locally advanced cervical cancer. Oncol Lett. 2015;10:1970–8.

PectaSol-C (Modified Citrus Pectin) Lime Infusion, 551g

Liners, F., Letesson, J. J., Didembourg, C., and Van Cutsem, P. (1989). Monoclonal antibodies against pectin: recognition of a conformation induced by calcium. Plant Physiol. 91, 1419–1424. doi: 10.1104/pp.91.4.1419 The inflammatory mediators (monocyte chemoattractant protein-1, osteopontin, cd68, cd80, cd44, and cd45) were elevated in spontaneously hypertensive rats and attenuated by MCP Zhao ZY, Liang L, Fan X, Yu Z, Hotchkiss AT, Wilk BJ, et al. The role of modified citrus pectin as an effective chelator of lead in children hospitalized with toxic lead levels. Alter Ther Health Med. 2008;14:34–8. MCP inhibited the survival of TAM in hypoxia by reducing glucose uptake via downregulation of GLUT-1 in vitro Emran TB, Islam F, Mitra S, Paul S, Nath N, Khan Z, Das R, Chandran D, Sharma R, Lima CMG, Awadh AAA, Almazni IA, Alhasaniah AH, Guiné RPF. Emran TB, et al. Molecules. 2022 Oct 31;27(21):7405. doi: 10.3390/molecules27217405. Molecules. 2022. PMID: 36364232 Free PMC article. Review.Despite no effect on body weight, adipose tissue weights or adiposity, MCP prevented adipose tissue fibrosis, inflammation and the increase in adipocyte differentiation markers in a model of diet-induced obesity Kolar, S., Barhoumi, R., Jones, C. K., Wesley, J., Lupton, J. R., Fan, Y. Y., et al. (2011). Interactive effects of fatty acid and butyrate-induced mitochondrial Ca(2)(+) loading and apoptosis in colonocytes. Cancer 117, 5294–5303. doi: 10.1002/cncr.26205